MayoClinic.org - Researchers in the North Central Cancer Treatment Group (NCCTG) have shown that patients who receive intravenous calcium and magnesium before and after the chemotherapy drug oxaliplatin for the treatment of advanced colon cancer experience a significantly reduced incidence and severity of neurological side effects (neurotoxicity). mayoclinic.org -研究人员在北中央癌症治疗组（ n cctg）表明，谁的病人接受静脉注射钙和镁之前和之后的化疗药物奥沙利铂治疗晚期结肠癌的经验，显着减少的发生率和严重的神经系统的副作用（神经毒性） 。 This reduction increases the likelihood that patients are able to complete a full course of treatment.这减少增加的可能性，患者能够完成整个疗程的治疗。 The findings were released May 15, 2008 as part of the 44th annual meeting of the American Society of Clinical Oncology.结果被释放2008年5月15日的一部分，第44次年度会议的美国临床肿瘤学协会。

“There have been limited studies and anecdotal stories about the effectiveness of calcium plus magnesium in reducing neurotoxicity caused by oxaliplatin,” says Daniel Nikcevich, MD, Ph.D., an oncologist at St. Mary’s Duluth Clinic in Duluth, Minn., a member of NCCTG and study co-chair. “有限制的研究和轶事故事的成效，钙，镁加在减少所造成的神经毒性奥沙利铂，说： ”丹尼尔nikcevich ，医学博士，博士研究生1肿瘤圣玛丽德卢斯诊所在德卢斯，明尼苏达州的一员， ncctg和研究的联席主席。

“We designed a double-blind, placebo-controlled study that confirmed the effectiveness of calcium plus magnesium in reducing debilitating neurological sensitivity associated with oxaliplatin, such as pain in the hands, fingers, feet and toes. “我们设计了一个双盲，安慰剂对照研究证实的成效，钙，镁加在减少神经衰弱的敏感性与奥沙利铂，如疼痛在手中，手指，脚和脚趾。 In the past, these side effects have caused patients to stop treatment and, therefore, not receive critical therapy.”在过去，这些副作用造成病人停止治疗，因此不接受关键疗法“ 。

Each year in the United States, 150,000 patients are diagnosed with colon cancer, and approximately 50 percent of those develop advanced colon cancer.每年在美国， 15.0万患者被诊断患结肠癌的，大约50 ％的受访者开发先进的结肠癌。 Oxaliplatin, in combination with other chemotherapy drugs such as 5-fluorouracil (5-FU), has emerged as a standard-of-care of first-line therapy for advanced colon cancer.奥沙利铂，再加上与其他化疗药物如5氟尿嘧啶（ 5 -F U） ，已成为一个标准的护理第一线治疗晚期结肠癌。 However, oxaliplatin can cause both acute and chronic cumulative sensory neurological problems including pain, numbness and tingling that can prevent patients from completing treatment.不过，奥沙利铂可能会导致双方的急性和慢性累积的感官神经问题，包括疼痛，麻木和刺痛感，可以防止病人完成治疗。

In the study, 50 of the 102 patients enrolled received intravenous calcium and magnesium along with oxaliplatin-based chemotherapy, while 52 patients received oxaliplatin-based adjuvant chemotherapy for colon cancer and an intravenous placebo.在这项研究中， 50对102例登记收到的静脉钙和镁随着奥沙利铂为基础的化疗，而患者52例，收到奥沙利铂为基础的辅助化疗的结肠癌和静脉注射安慰剂。 Study results showed that the use of calcium and magnesium infusions before and after oxaliplatin was associated with a significant decrease in the incidence and severity of neurotoxicity, and it also delayed the time to the onset of neurotoxicity on oxaliplatin therapy.研究结果表明，使用钙和镁的输液之前和之后，奥沙利铂是相关的显着下跌的发生率和严重的神经毒性，它也拖延了时间，发生神经毒性奥沙利铂治疗。

Calcium and magnesium are an easily administered, safe treatment option for oxaliplatin-induced neurotoxicity.钙和镁是一种易于管理，安全的治疗方法奥沙利铂诱导的神经毒性。 “Some initial reports from other studies claimed that the use of calcium and magnesium reduced the activity of oxaliplatin-based chemotherapy,” says Axel Grothey, MD, an oncologist at Mayo Clinic and study co-chair. “一些初步的报告，从其他的研究称，使用钙和镁减少活动奥沙利铂为基础的化疗，说： ”阿克塞尔grothey ，海事处，一肿瘤Mayo Clinic的研究的联席主席。 “However, we have definitive results from an independent, blinded radiologic review which demonstrates no negative influence of calcium and magnesium on the outcome for oxaliplatin-based chemotherapy.” “不过，我们有明确的结果，从一个独立的，利欲熏心的放射检讨这表明没有任何的负面影响钙和镁的研究结果为奥沙利铂为基础的化疗” 。

“Now that we have shown the effectiveness of calcium and magnesium in reducing oxaliplatin-induced neurotoxicity, a further step may be to evaluate the benefit of calcium and magnesium in reducing neurotoxicity caused by other medications,” says Dr. Nikcevich. “我们现在已显示成效，钙和镁减少奥沙利铂诱导的神经毒性，进一步加强可评估的利益，钙和镁减少所造成的神经毒性的其他药物，博士说： ” nikcevich 。 “Many other commonly used chemotherapy agents cause neurological sensitivity. “许多其他常用的化疗剂的原因神经的敏感性。 By applying our study design, we can test the effectiveness of calcium and magnesium when used with other treatments.”运用我们的研究设计，我们可以测试的成效，钙和镁的使用时，与其他治疗方法“ 。

This study was done as part of a program coordinated by Charles Loprinzi, MD, a medical oncologist at Mayo Clinic Rochester.本研究做的一个组成部分，计划协调由查尔斯loprinzi ，海事处，医疗肿瘤Mayo Clinic的罗彻斯特。 The program he leads has conducted more than 50 clinical trials designed to find ways to prevent or treat untoward symptoms related to cancer and cancer therapy.该计划他所领导进行了50多个临床试验，旨在寻求方法，以防止或治疗不愉快的症状有关的癌症和癌症的治疗。 This includes three trials to evaluate ways to treat established neuropathy caused by chemotherapy and three additional studies to try to prevent such neurotoxicity.这包括三个审判，以评估如何对待既定的神经病变所造成的化疗和另外三名研究，设法防止这种神经毒性。