Newswise — The debate about whether or not lycopene or some other phytochemicals from tomatoes might reduce prostate cancer risk is apparently not over. newswise -辩论与否，番茄红素或其他一些植物化学物质，从西红柿可能减少前列腺癌的风险是显然还没有结束。 Dr Edward Giovannucci from Harvard Medical School published an editorial in the July 2007 issue of the Journal of the National Cancer Institute that responded to a report in the same issue from the FDA that stated that a “very low level of comfort” existed with tomato and tomato product consumption decreasing the risk of prostate cancer.陈高凌博士吉欧凡努奇来自哈佛医学院发表社论说，在2007年7月发行的杂志上的国家癌症研究所认为，回应了一份报告，在同一问题上，由林业局即表示， "非常低的水平，舒适"的存在与番茄和番茄产品的消费量减少患前列腺癌。

The essence of Dr. Giovannucci’s argument that this conclusion may be flawed is that studies on lycopenes, tomatoes, and prostate cancer risk are influenced by PSA screening.本质博士吉欧凡努奇的说法，这个结论可能是有缺陷的是，研究lycopenes ，番茄，前列腺癌风险的影响港务集团检查。 He focused on how PSA screening influences the diagnosis and epidemiology of CaP and when during prostate carcinogenesis this is a factor.他的重点是如何筛选港务集团影响诊断和流行病学的帽子时，在前列腺癌，这是一个因素。 Prior to PSA most CaP patients had advanced cancers at diagnosis.前港务集团最上限，病人已提前癌症诊断。 However, in the PSA era, many diagnosed prostate cancers are low risk and indolent and likely would not have been detected in the pre-PSA era.然而，在变压吸附时代，很多诊断前列腺癌是低风险和懒散和可能，也不会被发现前港务集团时代。 In the absence of PSA screening, the diagnosis of carcinoma of the prostate follows a period of tumor proliferation that was stimulated by an internal or external factor.在没有前列腺特异性抗原筛查，诊断癌前列腺如下一个时期的肿瘤扩散，这是刺激内部或外部的因素。 However, in the PSA era he argues, the diagnosis of CaP often signifies that a man just happened to have a PSA test.然而，在变压吸附的时代，他辩称，诊断帽往往标志着一个人偏偏有一个变压吸附试验。

He used the data from the Health Professionals Follow-up Study (HPFS), a cohort evaluated for risk factors and cancer.他用数据从卫生专业人员随访研究（ hpfs ） ，队列评估风险因素及癌症的基因。 The HPFS reported that risk factors associated with an increased risk of CaP mortality were a higher incidence of CaP, an increased likelihood of poor prostate tumor differentiation, a preferential increase in the progression of highly differentiated tumors, or an increase CaP death rate independent of incidence stage at diagnosis or grade.该hpfs报道说，相关风险因素增加的风险上限，死亡率较高发病率的上限，增加的可能性穷人前列腺肿瘤分化，以优惠的增加，在循序渐进的高度分化的肿瘤，或提高上限死亡率独立的发病率这个阶段，诊断或职系。 In the HPFS, dietary factors associated with increased CaP mortality were not associated with an increase in incidence but rather increased tumor progression or an increase in the fatality rate.在hpfs ，饮食因素与增加帽死亡率没有联系增加了发病率，而是增加了肿瘤进展或增加病死率。 Thus, he states that studies not supporting an association between CaP lycopene, tomatoes, and CaP incident rates may reflect the impact of PSA screening.因此，他说，研究报告，不支持之间存在某种联系帽番茄红素，番茄，帽事件发生率可能反映的影响，港务集团检查。 Earlier studies performed in the pre-PSA era did show an association.早先的研究演出前港务集团时代，没有表现出任何关联。 The evidence associating tomatoes or lycopene and tumor progression are stronger for more advanced-stage cancers, which may be difficult to show in PSA screened cancers.证据缔或西红柿中番茄红素和肿瘤进展强，为更多的晚期癌症，其中可能有困难，以显示在变压吸附筛选癌症。 Furthermore, the HPFS straddled the pre-PSA and PSA era and from 1986-1992 there was an inverse association between tomato intake and total CaP incidence stronger for advanced-stage disease.此外， hpfs跨越前港务集团和标致时代，从1986年至1992年有一个逆协会之间的番茄摄取量和总发病率的上限为更强的晚期病。 During 1992-1998 the association was weak but a strong inverse association persisted for metastatic CaP.在1992-1998年，该协会薄弱，但强烈的逆协会坚持为转移性帽。 An analysis from 1992-2002 found no statistical association.分析，从1992-2002年，发现无统计学协会。

Dr. Giovannucci states that the relationship between prostate cancer risk and tomato and lycopene dietary intake is complex and the European Prospective Investigation into Cancer and Nutrition Study may help to better answer this question. J Nat Cancer Institute .博士吉欧凡努奇国之间的关系，前列腺癌的风险与番茄和番茄红素的饮食摄取量是一个复杂和欧洲准调查癌症与营养的研究可能有助于更好地回答这个问题。 j的nat癌症研究所 。 99(14):1060-2, July 2007 doi:10.1093/jnci/djm048 99 （ 14 ） :1060 - 2 ， 2007年7月在革新： 10.1093/jnci/djm048