How apparently healthy people may be developing diabetes before they know it - from silent inflammation. 显然，如何健康的人可能会罹患糖尿病之前，他们知道-从沉默的炎症。

UCLA News - In the first large-scale, multi-ethnic human study of its kind, researchers have confirmed the role played by three pro-inflammatory molecules known as cytokines in causing Type 2 diabetes and have identified these molecules as early biological markers that may be used to more accurately predict future diabetes in healthy individuals.洛杉矶消息-在首次大规模，多种族的人的此类研究，研究人员已经证实，所发挥的作用的三个亲炎性分子称为细胞因子导致2型糖尿病，并已确定了这些分子作为早期生物标志物，可用来更准确地预测未来糖尿病的健康人。

As reported in the August 15, 2007 issue of the journal Archives of Internal Medicine , scientists have identified three inflammatory cytokines, or messenger molecules — tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) — that may be one of the causes of Type 2 diabetes, which afflicts roughly 7 percent of the U.S. population.据报道，在2007年8月15日发行的杂志档案馆内科 ，科学家已经确定了三个炎性因子，或信使分子-肿瘤坏死因子- α （肿瘤坏死因子- α ） ，白细胞介素- 6（白介素- 6）和高敏c反应蛋白（ hs - crp ） -可能的原因之一， 2型糖尿病，发病大约百分之七的美国人口。 The principal investigator was Dr. Simin Liu, professor of epidemiology and medicine with a joint appointment at the UCLA School of Public Health and the David Geffen School of Medicine at UCLA.主要研究员博士四民刘教授流行病学和医学共同任命，在加州大学洛杉矶分校公共卫生学院和大卫格芬医学院在加州大学洛杉矶分校。

Type 2 diabetes is the most common form of diabetes and accounts for about 90 to 95 percent of all diabetes cases. 2型糖尿病是最常见的一种糖尿病，约占90 ％至95 ％的糖尿病病例。 People with this condition produce insulin, but their bodies do not make enough of it or can’t use it effectively.患有此种状况产生胰岛素，但他们的尸体没有做出足够的，它还是不能使用它有效。

Low-grade, chronic inflammation of the body, reflected by elevated levels of inflammatory cytokines in the blood stream, may promote insulin resistance in the liver, muscles and the vascular endothelium cells, the layer of thin, flat cells that lines the interior surface of blood vessels.低品位，慢性炎症的身体，反映升高炎性因子在血液流，可以促进胰岛素抵抗在肝脏，肌肉和血管内皮细胞层，薄，单位细胞系内部表面血管。 Inflammation can last for years before leading to Type 2 diabetes, hypertension or cardiovascular disease.炎症可长达几年前导致2型糖尿病，高血压或心血管疾病。

A blood test that looks for high levels of inflammatory cytokines could serve as an accurate predictor of diabetes in still-healthy people, years ahead of traditional risk-factor indicators such as obesity or insulin resistance.验血，看高水平的炎性细胞因子可作为一种准确预测糖尿病仍然健康的人， 1980年翻两番的传统危险因素指标如肥胖或胰岛素抵抗。 The finding also has implications for cancer research, according to Liu, since people with diabetes are at greater risk of developing breast and colon cancers.调查结果也影响癌症研究，据刘，因为糖尿病人的风险更大发展乳腺癌和结肠癌。

“This is a final confirmation of earlier studies about the underlying biology behind Type 2 diabetes,” said Liu, who is also a member of UCLA’s Jonsson Cancer Center. "这是一个最后确认早先研究的基本生物学背后的2型糖尿病， "刘说，他也是一名成员加州大学洛杉矶分校的安德森癌症中心。

But those previous studies, Liu said, were either very small or were animal studies.但这些以往的研究，刘建超说，要么很小或动物的研究。 The UCLA study was more extensive in scale and involved human study volunteers.加州大学洛杉矶分校的研究更广泛的规模和涉及人体的研究志愿者。

“Our study identified 1,600 new cases of diabetes and measured the blood markers before they developed the disease,” he said. "我们的研究发现1600例新的糖尿病和测量血液标记，然后发达疾病， "他说。

Researchers took advantage of the Women’s Health Initiative Observational Study (WHIO), an ongoing, long-term study examining the association between behavior, socioeconomic status, diet and other factors and their effect on women’s health.研究者们利用妇女健康倡议观测研究（ whio ） ，是一项持续，长期的学习研究协会之间的行为，社会经济地位，饮食和其他因素的影响，对妇女的健康。 Liu and his colleagues took baseline-level measurements of inflammatory cytokines in apparently healthy women between the ages of 50 and 79 who had no signs of diabetes, then tracked their health for the next six years.刘和他的同事们采取基线水平测量炎性因子显然健康妇女年龄介于50至79名没有迹象显示糖尿病，然后跟踪他们的健康，为今后六年。

The WHIO involved some 82,000 postmenopausal women of various ethnicities, including whites, blacks, Hispanics, and Asians and Pacific Islanders.该whio涉及大约82000名绝经后妇女的各种种族，包括白人，黑人，西班牙裔，亚裔及太平洋岛民。 At the time of follow-up, Liu and his colleagues compared 1,584 women, now diagnosed with Type 2 diabetes, and matched them by age, ethnicity and other factors to 2,198 other women in the study who remained free of the disease.在当时的后续行动，刘和他的同事们相比， 1584女，现在诊断出患有2型糖尿病，他们匹配的年龄，种族和其它因素2198其他妇女在研究人仍然无口蹄疫。

While all three cytokines were found to be significantly related to an increased risk of clinical diabetes, one — hs-CRP — appeared to be a more consistent predictor of increased risk in all four ethnic groups.而所有这三个因子被证实是显着相关的危险增加临床糖尿病，一-协-通行-似乎是一个较为一致的预测风险增加，在所有四个族群。 These associations were independent of the traditional risk factors such as obesity and elevated levels of glucose and insulin previously reported by Liu and his colleagues in the same multiethnic sample.这些协会都是独立的传统危险因素，如肥胖及升高血糖及胰岛素先前报导刘和他的同事在同样多的样本。

“The pro-inflammatory state is often linked to obesity, which can lead to insulin resistance,” Liu said. "亲炎症状态往往与肥胖，可导致胰岛素抵抗， "刘说。 “So identifying these markers by a simple blood test well before a disease begins not only can help improve mechanistic understanding of the disease but also offer alternatives to lifestyle — hitting an optimal balance of nutrition, for example, and engaging in more exercise — relatively simple things that can prevent disease” by reducing the inflammation that precedes development of pre-diabetes and type 2 diabetes. "所以查明这些标志由一个简单的血液测试井前开始病不仅能改善机械对该病的了解，但也提供替代生活方式-创最佳平衡的营养，例如，从事多运动-比较简单东西可以防止病" ，减少炎症的发展先行预型糖尿病和2型糖尿病。