American Association of Cancer Research - Obesity and aversion to exercise have become hallmarks of modern society, and a new study suggests that a blood protein linked to these lifestyle factors may be an indicator for an increased risk of developing pancreatic cancer.美洲协会癌症研究肥胖和厌恶运动已经成为现代社会标志,是一项新研究显示,血液中的蛋白质相联系的生活方式,这些因素可能是一个指标,增加患胰腺癌的发病率. Researchers from the Dana Farber Cancer Institute report their findings in the August 15, 2007 issue of Cancer Research .研究者从达纳法伯癌症研究所的报告,他们的研究结果在2007年8月15日发行的癌症研究 .

In a study of 144 patients with pancreatic cancer and 429 people without the disease, a subset of patients with low blood levels of a protein called IGFBP-1 were at approximately twice the risk of developing pancreatic cancer.一项研究144胰腺癌患者和429人无病,子患者低血蛋白的含量称为胰岛素1名约两倍,患胰腺癌的发病率. Low blood levels of this protein have previously been linked to excess weight and lack of physical activity.低血蛋白以前曾联系过重和缺乏体力活动. Their data originated from tens of thousands of men and women enrolled in four large-scale cohort studies - the Health Professionals Follow-Up Study, the Nurses’ Health Study, the Physicians’ Health Study and the Women’s Health Initiative Observational Study - all of which followed the health of participants over numerous years.其数据来源于成千上万的男人和妇女在入学四个大型队列研究-卫生专业人员的后续研究,护士健康研究中,医师健康研究中心和妇女健康倡议观测研究所有其中,然后生参加了许多年. The study was supported by The Lustgarten Foundation for Pancreatic Cancer Research and the National Cancer Institute.研究辅以lustgarten基金会胰腺癌研究和美国国家癌症研究所.

“The prognosis for many patients with pancreatic cancer remains poor, so it is vitally important that we indentify and better understand risk factors for the disease, particularly risk factors that are modifiable” said lead study author, Brian M. Wolpin, M.D., attending physician at Dana Farber Cancer Institute. "预后许多胰腺癌患者仍然很差,所以这是极其重要的是我们事务识别并更好地理解风险因素,为疾病,尤其是风险因素,是编辑说: "带领研究的作者,布莱恩米wolpin ,医学博士,主治医师在达纳法伯癌症研究所. “In addition to cigarette smoking, exercise and weight control appear to be important modifiable risk factors for this difficult disease.” "除了吸烟,运动和控制体重似乎是重要的可改变风险因素,为这一疑难病"

Pancreatic cancer is one of the leading causes of cancer death in America - over 33,000 Americans will likely die from the disease in 2007, according to projections from the American Cancer Society.胰腺癌的危险之一是导致癌症死亡的,在美国超过33000名美国人很可能会死于这种疾病, 2007年,根据预测,由美国癌症学会. Studies indicate that smoking is responsible for about 25 percent of pancreatic cancer cases, and obesity and lack of exercise may account for a similar amount, Dr. Wolpin said.研究表明,吸烟是负责为25 %左右,胰腺癌的情况下,肥胖和缺乏锻炼,可能到了类似的款项, wolpin博士说.

According to Dr. Wolpin, previous research has linked IGFBP-1 (insulin-like growth factor binding protein one) with increased risk of colorectal and endometrial cancer.据wolpin博士,先前的研究已挂胰岛素-1结合蛋白(胰岛素样生长因子结合蛋白之一)的风险增加结肠癌和子宫内膜癌. Like its name suggests, IGFBP-1 is a molecule that binds with insulin-like growth factor (IGF), a hormone normally associated with growth and development.像它的名字那样, igfbp - 1的是一个分子的结合与胰岛素样生长因子(胰岛素) ,激素通常与经济增长和发展. In the laboratory, IGF has been noted to increase the growth of pancreatic cancer cells.在实验室里,胰岛素已经注意到进一步增加胰腺癌细胞. Since one role of IGFBP-1 is to sequester IGF, Dr. Wolpin and his colleagues were interested as to whether people who developed pancreatic cancer had lower blood levels of the IGFBP-1 protein.自作用之一igfbp - 1的是胰岛素死骨, wolpin博士和他的同事们的兴趣,至于是否人发达胰腺癌降低了血中的胰岛素蛋白-1 .

To study the relationship between IGFBP-1 and pancreatic cancer, Dr. Wolpin and his colleagues chose pancreatic cancer patients enrolled in one of the four cohort studies and with blood drawn four or more years before developing cancer.关系研究igfbp - 1和胰腺癌wolpin博士和他的同事选择胰腺癌患者报名参加其中的4个队列研究与采血四年或以上之前患癌症. The blood levels of IGFBP-1 from these patients were compared to those taken from 429 cancer-free people also enrolled in one of the cohort studies.血中胰岛素- 1 ,从这些患者相比,这些抽取429名无肺癌的人也参加其中的队列研究. According to their findings, patients with low blood levels of IGFBP-1 were nearly twice as likely to develop pancreatic cancer.据他们调查,患者血液中的低层次igfbp - 1的人的两倍,可能会发展为胰腺癌.

“We still have much to learn about the mechanisms by which obesity and sedentary lifestyle may contribute to the risk of pancreatic cancer,” Dr. Wolpin said. "我们仍然有很多需要学习的约机制,其中肥胖和久坐的生活方式可能有助于患胰腺癌的危险, " wolpin博士说. “While it is too early to discuss IGFBP-1 as a suitable blood marker for pancreatic cancer, it is never too early to address the lifestyle issues that may contribute to low levels of IGFBP-1 and to an elevated risk of this difficult disease,” pancreatic cancer. " ,而实在是言之过早讨论胰岛素- 1作为一个合适的血液标记为胰腺癌,它从来都不会太早,以解决生活问题,可能有助于低igfbp - 1和一个高风险的这种疑难病, "胰腺癌.