American Association for Cancer Research - Concentrated phytochemicals like EGCG derived from green tea dramatically boosted production of a group of key detoxification enzymes in people with low levels of these beneficial GST proteins, according to researchers at Arizona Cancer Center.美国癌症研究协会的浓缩植物绿茶一样,从绿茶,大幅度提高产量的一组解毒关键酶的人水平低,这些有益的gst蛋白质,据研究者在亚利桑那癌症中心.

These findings, published in the August 2007 issue of Cancer Epidemiology, Biomarkers & Prevention , a journal of the American Association for Cancer Research, suggest that a green tea concentrate might help some people strengthen their metabolic defense against toxins capable of causing cancer.这些发现刊登在2007年8月发行的癌症流行病学,生物标记及预防 ,该杂志在美国癌症研究协会的经验表明,绿茶精矿可能帮助一些人加强其新陈代谢防御毒素能够导致癌症.

In a study of 42 people, the concentrate - composed of chemicals known as green tea catechins in amounts equal to that found in 8-16 cups of green tea - boosted production of the enzymes, which belong to the glutathione S-transferase (GST) family, by as much as 80 percent in some participants.在一项研究,其中42人,集中力量组成的化学物质称为绿茶儿茶素相加等于发现,在8-16杯绿茶带动生产酶,其中属于中谷胱甘肽转移酶( gst )家庭中,高达百分之八十,在一些与会者.

GST enzymes are believed to be crucial to the body’s defense against cancer-causing chemicals and other toxins, according to the study’s lead investigator, H.-H.开征酶被认为是对身体的防御致癌物质和其他毒素,根据该项研究的首席调查员, h.-h. Sherry Chow, Ph.D., a research associate professor at the University of Arizona.周群英,博士,研究助理教授,在亚利桑那大学. They modify the cancer-causing molecules that would otherwise damage cellular DNA, thus rendering them inert.他们改变致癌物质的分子,否则会破坏细胞基因,从而使它们的惰性.

“They actually convert known carcinogens to non-toxic chemicals, and studies have shown a correlation between deficient expression of these enzymes and increased risk of developing some cancers,” Chow said. "其实他们把已知的致癌物质,以非毒性化学物质,研究显示有相关性的缺陷表达这些酶和风险增加发展中国家某些癌症, "周说.

“Expression of this enzyme varies dramatically in people due to genetic variation and environmental factors,” Chow added. "表达了这种酶参差人因遗传变异和环境因素, "周说. “Green tea catechins somehow increase gene expression of these enzymes, which can be an advantage to people with low levels to start with.” "绿茶儿茶素增加某种基因表达这些酶,可利用一个人的低层次做起"

Green tea has long been of interest to researchers given studies that have shown populations in which it is often consumed, such as the Chinese and Japanese, generally have lower rates of cancer.绿茶一直感兴趣的研究人员的研究表明,人群中,人们经常食用的,如中国和日本,一般有较低的癌症. To find out if green tea can protect against cancer, the NCI has sponsored a number of rigorous scientific studies testing capsules of the extract, Polyphenon E, that have been prepared in Japan to meet exact specifications.看看绿茶可以预防癌症,癌症已赞助了一些严格的科学试验研究,制成胶囊,提取茶多酚电子,已准备在日本,以满足精确的规格. These pills contain epigallocatechin gallate (EGCG), a catechin known for its potent antioxidant activity, and are currently being tested against a variety of cancers in clinical trials.这些药丸含有儿茶素(绿茶) ,儿茶素著称,其强大的抗氧化活性,并正在测试,对各种癌症的临床试验.

This study was designed to see if green tea catechin concentrate had any effect on the levels of GST enzymes in healthy individuals - research that could explain the tea’s anti-cancer properties.这一研究的目的是看看绿茶儿茶素集中了任何对各级相约酶在正常人研究,可以解释茶叶中的防癌特性. Healthy volunteers were asked to abstain from consuming any tea or tea-related products for four weeks.健康志愿者被要求弃权,不进食任何茶或茶相关产品,为四个星期. At the end of this “washout period,” blood was drawn and baseline GST enzyme levels were determined for each participant.在结束这次"白卷期间, "血的教训和基线税酶水平,确定了每个参与者. Then, the volunteers were asked to take four Polyphenon E capsules, for a total of 800 milligrams of EGCG, each morning on an empty stomach for four weeks and to abstain from drinking tea or eating many cruciferous vegetables, which contain other beneficial chemicals.然后,志愿者被要求采取四项电子茶多酚胶囊,共计800毫克绿茶,每天早上就饿着肚子为四个星期,并戒除喝茶或吃很多十字花科蔬菜中,含有其他有益的化学物质. Another blood sample was taken after four weeks, and GST activity was determined.另血液样本是在4个星期之后,和gst活性测定.

Researchers found that use of Polyphenon E enhanced GST activity when data from all participants were included for analysis.研究人员发现,使用电子茶多酚增强gst活性数据时,从所有参加者都被列入分析. But it had its most significant effect in volunteers whose baseline blood measurements showed low GST activity - an 80 percent increase compared to baseline GST activity.但它最重要的作用,在志愿者的基线测量血液呈低税活性增加了80 %相比基线gst活性. Activity did not change in volunteers with medium GST expression, or in those with the highest levels, GST seemed to decrease slightly although researchers believe that decline was due to random variation.活动并没有改变在健康志愿者中表达gst ,或在那些具有最高的水平,税似乎略有下降,但研究人员认为,这一下降是由于随机变异.

“This is the first clinical study to show proof that chemicals in green tea can increase detoxification enzymes in humans,” Chow said. "这是首次临床研究,以证明他们在化学品绿茶可以提高解毒酶在人体周伟焜表示, " . “There may be other mechanism in play by which green tea may protect against cancer development, but this is a good place to start.” "可能还有其他的机制在发挥作用,其中绿茶可防癌的发展,但是这是一个很好的地方做起. "