Boston University - Research has found that a particular statin, simvastatin, reduces the incidence of Alzheimer’s disease and Parkinson’s disease by almost 50 percent.波士顿大学的研究发现,尤其是他汀,辛伐他汀,发生率降低阿尔茨海默氏病和帕金森氏病几乎50 % . This is the first study to suggest that statins might reduce the incidence of Parkinson’s disease.这是首次研究显示他汀类可减少发病帕金森病. These findings by researchers from the Boston University School of Medicine (BUSM) will be published in the July 2007 online open access journal BioMed Central (BMC) Medicine.这些研究结果,科学家从波士顿大学医学院( busm )将刊登在2007年7月在网上公开查阅杂志生物医学中心 (骨髓)的医学.

Alzheimer’s disease or dementia is one of the major public health threats that individuals face as they age.阿尔茨海默氏症或老年痴呆症是一个主要的公共健康威胁,个人面对的,因为他们的年龄. Statins are a class of medications that reduce cholesterol by inhibiting HMG-CoA reductase, and simvastatin is one that is able to cross the blood-brain barrier to get into the brain. statins是一类药物降低胆固醇,抑制hmgcoa还原酶,辛伐他汀之一,是能穿过血-脑屏障进入脑组织.

The scientists used data from the US Veterans Affairs Database on 4.5 million subjects, and looked at data on over 700,000 simvastatin users.科学家们使用的数据来自美国退伍军人事务数据库,对4.5万科目,并期望在数据超过70万用户的辛伐他汀. The team targeted those aged 65 or over with no prior diagnosis of Alzheimer’s disease, who had been taking statins for at least seven months.小组针对那些年龄在65岁或以上,没有事先诊断阿尔茨海默氏症,曾经服用至少七个月.

Using three different models for analysis, the researchers examined the effects of three different statins (atorvastatin, lovastatin and simvastatin) and found that simvastatin showed a strong reduction in the incidence of Alzheimer’s disease in each of the models.用三种不同的模式进行分析,研究人员对3种他汀(阿伐他汀,洛伐他汀和辛伐他汀) ,并发现辛伐他汀表现出强烈的发病率减少阿尔茨海默病的每一种模式. The data also showed the same statin was associated with a reduced incidence of Parkinson’s disease.数据还显示,同样是他汀,与张丽玲帕金森病.

Lovastatin was not found to have any significant effect on dementia, and neither atorvastatin nor lovastatin were associated with a reduction in the number of cases of Parkinson’s disease.洛伐他汀没有被发现有重大的影响性痴呆,既不伐洛伐他汀,也都是与缩例帕金森病.

The researchers speculate that the selective benefit observed with simvastatin might be due to the combination of high potency and the ability to enter the brain.研究者推测,有选择性地造福观察辛伐他汀可能是由于结合高效,并有能力进入大脑.

“The strength of reduction of incidence of dementia with simvastatin is striking,” said lead author Benjamin Wolozin, MD, PhD, a professor of pharmacology at BUSM. "的力量,降低发病率,老年痴呆与辛伐他汀显着, "说,导致作者本杰明wolozin ,海事,博士,教授,药理学busm .

According to the researchers, multiple past studies have investigated whether statin treatment might be of benefit for people with dementia or at risk for dementia, however, these studies have produced conflicting results.根据这一研究,在过去多研究调查,究竟他汀治疗可能有利于为老人痴呆症或痴呆风险,但这些研究已产生矛盾的结果. “The strength of this study is that it examines the issue with a huge amount of statistical power and uses existing data to look prospectively at Alzheimer’s and Parkinson’s,” added Wolozin. "的力量,这项研究就是研究问题,大量的统计力量,并使用现有的数据来看,以前瞻性,在阿尔茨海默氏病和帕金森氏病" wolozin .

Editorial note: These numbers on simvastatin use and risk for Alzhiemer’s and Parkinson’s dementia are impressive.编者注:这些号码,使用辛伐他汀和风险ad氏病和帕金森痴呆的印象. People with a strong family history of Alzheimer’s or even mixed dementia who are already on a different statin may want to speak with their primary care doctor about this study and the advisability of using simvastatin - Dr. Z.人们具有强烈的家族病史阿尔茨海默甚至混合性痴呆者已有一套不同他汀类可想谈谈自己的初级保健医生的这项研究,并宜采用辛伐他汀博士z.