New dissertation provides fascinating insights into how exercise and the antidepressant Lexapro have different but complementary antidepressant effects in the brain.新的论文,提供引人入胜的见解如何行使和抗抑郁lexapro之间不同但具有互补性的抗抑郁作用,在脑.

Karolinska Institutet - Exercise provides a clinical benefit for depressed patients comparable to that of antidepressants - this has been shown by previous research.卡罗林斯卡研究所运动提供了临床受益,为抑郁症患者相比,抗抑郁药,这已显示先前的研究. Now Astrid Bjørnebekk at Karolinska Institutet has explained how and why this can happen: exercise not only stimulates the production of new brain cells, it enhances the integration of those new cells into functional neuronal networks - a feat that the SSRI escitalopram was unable to do by itself.现在的astridbjørnebekk在卡洛林斯卡研究所解释何以会发生这种事情:演习不仅刺激产生新的脑细胞,它增强了整合这些新的细胞分化为神经功能网络的一个壮举,ssri的普仑是无法做到的事. This latter point was missed in the original press release for this research, but this enhanced neuronal integration is an important finding.这后一点,错过了,在原来的新闻稿这项研究,但这一增强神经融合是一个重要的发现.

In a series of scientific experiments, Dr. Bjørnebekk has searched for the underlying biological mechanisms that explain why exercise can be a distinct “psychotropic” therapy for depression and has also compared its neurobiological effects with the effects of pharmacological treatment with an SSRI drug.在一系列的科学实验,博士bjørnebekk探索内在生物学机制可以解释为什么运动可以是一种独特的"精神"疗法抑郁也相比,其生物学效应的影响,药物治疗ssri的药物. She is, in effect, researching the “psychopharmacology of exercise.”她,实际上是研究"的精神药演习"

For those who wish to read the scientific details, a free summary of Dr. Bjørnebekk’s dissertation can be found online here:对于那些想读科学细节免费纪要bjørnebekk博士的学位论文,可上网浏览:

On antidepressant effects of running and SSRIs: Focus on hippocampus and striatal dopamine pathways对抗抑郁作用的运行和脱落:把重点放在海马和纹状体多巴胺通路 ..

Abstracts from two of her published studies can be found here:文摘从她的两个已发表的研究可以在这里找到:

Antidepressant effect of running is associated with increased hippocampal cell proliferation抗抑郁作用跑步是与增加海马细胞增殖

Effects of running on neuropeptide Y, opiates, and brain cell proliferation in an animal model of depression影响运行的神经肽,阿片类药物,脑细胞增殖,在动物模型的抑郁 ..

The experimental studies were conducted on rats.实验进行了研究老鼠. The results show that both exercise and antidepressants increase the formation of new cells in the hippocampus, which is an area of the brain important to memory and learning, and which can shrink in size during depression.结果表明,体育锻炼和抗抑郁药增加形成新的细胞,在海马,这是一个方面的重要脑记忆和学习并能缩小在抑郁. Astrid Bjørnebekk’s studies show that the use of the SSRI escitalopram (Lexapro) in the absence of the “environmental enrichment” provided by running did not lead to a significant antidepressant response.bjørnebekk的astrid的研究表明,使用该ssri的普仑(与lexapro),在没有"环境致富"提供运行没有导致显着的抗抑郁反应. Running, however, improved the treatment response, and appeared to regulate several brain chemicals important for full antidepressant response, such as neuropeptide Y and brain-derived neurotrophic factor (BDNF).跑步,然而,提高治疗反应,并出现一些调节大脑化学物质重要的抗抑郁剂充分反应,如神经肽和脑源性神经营养因子(脑源性神经营养因子). Her study shows that exercise is a very good complement to psychotropic medications in this animal model of depression.她的研究显示,运动是一个很好的补充,精神科药物,在这种动物模型中的抑郁症状.

She states, “What is interesting is that the effect of antidepressant therapy can be greatly strengthened by external environmental factors,” such as exercise.她表示,"什么是有趣的是,对抗抑郁治疗,可大大加强外部环境因素",如演习.