Newswise - Prostate cancer research funded by the NIH suggests that a diet high in the kind of omega-3 fatty acids found in fish oil and certain types of fish might improve the prognosis of men who have a genetic tendency towards prostate cancer.新闻立前列腺癌研究资助的研究所的研究显示,饮食高,在什么样的奥米伽-3脂肪酸酸类发现鱼油和某些种类的鱼可能改善预后的男人有一种遗传趋向前列腺癌.

“This study clearly shows that diet can tip the balance toward a good or a bad outcome,” said senior researcher Yong Q. Chen, Ph.D., from Wake Forest University School of Medicine."这项研究表明,饮食习惯可以轻重走向好的还是坏的结果,说:"高级研究员勇问:陈博士,从随着森林大学医学院的. “It’s possible that a change in diet could mean the difference between dying from the disease and surviving with it.”"这可能是改变饮食习惯,可能意味着差别死于疾病和生存."

In mice that were engineered with a genetic defect that caused prostate cancer, a diet high in omega-3 fatty acids beginning at birth reduced tumor growth, slowed disease progression and increased survival.在小鼠,重整与遗传缺陷导致前列腺癌饮食高奥米加-3脂肪酸从出生时减少肿瘤生长,减缓病情发展和延长生存. The research is reported online in the Journal of Clinical Investigation and will appear in the July 2, 2007 print issue.该研究报告是在网上日刊临床调查将刊登在7月2日2007打印问题.

Prostate cancer is the most frequently diagnosed cancer and is a leading cause of death in men in the United States.前列腺癌是最常患上的癌症,是导致死亡的男性美国. Population studies have suggested that consumption of fish or fish oil reduces prostate cancer incidence.人口研究显示,食用鱼类或鱼油可减少前列腺癌的发病率. However, these investigations have been hampered by the difficulty people have in accurately reporting their dietary intake.但是,这些案件已阻碍了人们难有准确地报告其食物摄入量.

The goal of the current study was to explore gene-diet interactions in prostate cancer.此轮探讨基因-饮食交互作用前列腺癌. It involved mice that were engineered with a genetic defect - they lacked a tumor suppressor gene and spontaneously developed prostate cancer.它涉及到小鼠重整,有遗传缺陷,他们缺乏一种抑癌基因,并自发研制前列腺癌. This gene (Pten) is absent in 60 to 70 percent of metastatic cancers in humans.这个基因(PTEN基因),是在缺席60到70%的转移性癌症的人类.

The engineered mice and “wild-type” (or non-engineered) mice were fed varying levels of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs).该工程小鼠和"野生型"(又称非遗传工程)小鼠喂食不同程度的奥米伽-3和奥米伽-6多不饱和脂肪酸(不饱和脂肪酸). Both are “essential” fatty acids, which means the body needs them for proper cell function but cannot produce them.无论是"必不可少"的脂肪酸,即人体需要他们妥善细胞功能,但不能大量生产. Many vegetable oils contain omega-6 PUFA.许多植物油中含有奥米伽-6脂肪酸. Fish like mackerel, lake trout, herring, sardines, albacore tuna and salmon are high in omega-3 fatty acids.鱼类如鲭鱼,湖鳟鱼,鲱鱼,沙丁鱼,长鳍金枪鱼和鲑鱼是高奥米加-3脂肪酸.

Nutritionists recommend that people consume equal proportions of omega-3 and omega-6 PUFA.营养学家建议人们食用各占欧米茄3和欧米茄6脂肪酸. However, in current western diets, the proportion of omega-6 to omega-3 is between 30 and 50 to one.但是,在目前的西方饮食结构,比例欧米茄6至-3为30至50比1.

The mice were fed either a diet high in omega-3 (ratio of omega-6 to omega-3 was 1:1) a diet low in omega 3 (ratio omega-6 to omega-3 was 20:1), or a diet high in omega-6 (ratio of omega-6 to omega-3 was 40:1).小鼠喂食要么节食高奥米加-3(比率欧米茄6至-31:1)饮食低在奥米加3(比率欧米茄6至-3为20:1),或饮食高奥米伽-6(比率欧米茄6奥米加-3是40:1). The scientists compared survival rates and weighed the animals’ prostates to measure tumor progression.科学家比较生存率及衡量动物的前列腺测量肿瘤进展.

Mice with the tumor suppressor gene remained free of tumors and had 100 percent survival, regardless of diet.小鼠的抑癌基因维持免费肿瘤,并已百分之百存活,不论饮食习惯. In mice with the gene defect, survival was 60 percent in animals on the high omega-3 diet, 10 percent in those on the low omega-3 diet and 0 percent in those on the high omega-6 diet.在小鼠的基因缺陷,存活率为60%,在动物中的高奥米加-3饮食,10%,对那些低奥米加-3饮食和0比那些高奥米伽-6的饮食习惯.

“This suggests that if you have good genes, it may not matter too much what you eat,” said Chen, a professor of cancer biology."这意味着,如果你有良好的基因,它可能不会太多,你吃",陈水扁说,教授癌症生物学. “But if you have a gene that makes you susceptible to prostate cancer, your diet can tip the balance."但如果你有一个基因,使你容易与前列腺癌,你的饮食习惯可以不知轻重. Our data demonstrate the importance of gene-diet interactions, and that genetic cancer risk can be modified favorable by omega-3 PUFA.”我们的数据显示了基因-饮食交互作用,而癌症的遗传风险,可修饰有利的欧米加-3脂肪酸."

Chen said dietary changes may be particularly beneficial in people prone to prostate cancer because the disease is usually diagnosed in older men and the tumors are slow-growing.他说,改变饮食可能特别有益的人易前列腺癌,因为这种疾病通常诊断老年男性和肿瘤生长缓慢. It’s possible that eating a high omega-3 diet could delay tumor development or progression long enough for the man to live out his natural lifespan with prostate cancer.它可能吃高奥米加-3饮食能延缓肿瘤的发展或进展够长的男子活出他的自然寿命与前列腺癌.

He noted that the mice got lifetime exposure of omega-3 and that some people may not be willing to change their diets until they develop cancer.他指出,小鼠的寿命得到曝光奥米加-3,而有些人可能不会愿意改变他们的饮食,直到他们患上肝癌. He hopes to study whether there would be beneficial effects of adding omega-3 PUFA to the diet after tumors have developed.他希望研究是否会有利于饲料中添加欧米加-3脂肪酸的饮食习惯后,有肿瘤发达.

He cautioned that the effects were obtained with the omega-3s found in fish oil and that omega-3s from flaxseed oil and other plants may not provide the same results.他告诫说,在效果获得与欧米茄3S技术发现鱼油,而欧米茄3S技术,从亚麻籽油和其他植物可能无法提供相同的结果. Those interested in an overview of omega-3 fatty acids and ways of supplementing your family’s diet with them can obtain our free omega-3 user guide by signing up for our monthly newsletter,有意概述奥米伽-3脂肪酸,以及如何补充你家的饮食习惯与他们可以获得我们免费奥米加-3用户指南签署的每月通讯, The iHealthBulletin该ihealthbulletin , from our home page (http://www.iHealthBulletin.com).,从我们的主页(http://www.ihealthbulletin.com).

“Our data imply a beneficial effect of omega-3 PUFA on delaying the onset of human prostate cancer,” Chen said."我们的数据暗示了有益作用奥米加-3PUFA对延缓人体前列腺癌",陈明说.