Scientists from the Department of Biochemistry and Molecular Biology of the University of Granada have shown that feeding chickens a high cholesterol diet causes changes in the gene expression of the smooth muscle cells of the (chicken) aorta at the early stages of atherosclerosis.科学家部生物化学与分子生物学格拉纳达大学的显示饲养肉鸡高胆固醇饮食变化而导致的基因表达的平滑肌细胞中的(鸡),主动脉在早期动脉粥样硬化. This study links cholesterol intake with the expression of genes that codify the production of certain proteins even before any atherosclerosis is detected on blood vessel walls.这项研究环节胆固醇摄入量与基因表达的编纂生产某些蛋白质,即使在任何动脉粥样硬化患者的血管壁.

Experts carried out research on atherosclerosis from its earliest stages to discover the origin of atheromatous plaques - fatty deposits that gradually and irregularly form in the main arteries, eventually causing the narrowing of the blood vessel.专家进行研究,对动脉粥样硬化从早期发现的起源动脉粥样斑块脂肪存款,并逐渐形成不规则的主要动脉,最终导致狭窄的血管. Although there are many causes for this disease, UGR scientists focused on the transformation of smooth muscle cells (SMCs) into de-differentiated and proliferative cells that are able to carry lipids in culture.虽然有许多原因,为这一疾病ugr科学家集中改造平滑肌细胞(SMC)进入脱分化和增殖的细胞,能携带脂类的文化. In this experiment, cells from animals fed with a control diet are different from those fed a high cholesterol diet.在此实验中,从细胞动物饲喂,以控制饮食,是有别于喂以高胆固醇饮食. Experts carried out the early cell atherosclerosis experiment with chickens, as these birds develop atherosclerosis very rapidly: a 20-day high cholesterol diet is enough to detect atheromatous plaques in their arteries.专家们进行了早期动脉粥样硬化的细胞实验鸡,因为这些鸟动脉硬化的发展十分迅速:为期20天的高胆固醇饮食,是足以发现粥样硬化斑块的动脉.

Experts obtained SMCs from arteries before the formation of the plaques.专家们获得的,由校董会前动脉形成的斑块. Ten days after the start of the high cholesterol diet - when atheromatous plaques are not still visible using an electron microscope - aortic SMCs were extracted and cultured.十天后开始的高胆固醇饮食时,动脉粥样斑块不仍清晰可见使用电子显微镜-平滑肌细胞培养液中. Experts cultured SMC-Cs (obtained from animals without a cholesterol dietary supplement) and SMC-Chs (extracted from animals with cholesterol dietary supplement) under the same conditions.专家平滑肌细胞铯(从动物无胆固醇饮食补充剂)和SMC-货物(摘自动物胆固醇饮食补充剂)在相同的条件下. After genetic analysis, scientists confirmed that compared to the control samples (without cholesterol diet) modifications occurred in the cells from birds fed a high cholesterol diet.经过遗传分析,科学家证实,与对照样品(无胆固醇饮食)的改变发生在细胞从鸟类喂养高胆固醇饮食. Differences showed that dietary cholesterol causes changes in messenger RNA synthesis in proteins related to lipid metabolism control, proliferation and apoptosis (programmed cell death) and, therefore, that the high cholesterol diet has an influence on gene expression in smooth muscle cells of the aorta.差异显示,饮食中胆固醇的变化而导致的信使RNA的合成,蛋白质与脂肪代谢控制,增殖和凋亡(程序性细胞死亡),因此,高胆固醇饮食有重要影响的基因表达平滑肌细胞中的主动脉.

In another study, these experts discovered that, while cholesterol causes changes in gene expression, fish oil reverts such changes .在另一项研究表明,这些专家发现,而胆固醇的变化而导致基因表达,鱼油重归这种变化. In this case, scientists fed the animals with a high cholesterol diet for ten days, then substituted fish oil (rich in omega-3 polyunsaturated fatty acids) for cholesterol for another ten days.在这种情况下,科学家们喂动物与高胆固醇饮食为十天,然后取代鱼油(富含欧米加-3不饱和脂肪酸)的胆固醇又十天. (Science News of the Universidad de Granada).(科学新闻的标Universidadde格拉纳达).