Society for Neuroscience - A study of alcohol-dependent animals shows that a newly discovered compound that blocks chemical signals active during the brain’s response to stress effectively stops excessive drinking and prevents relapse into alcohol abuse.社会的神经-一个研究酒精依赖动物表明，一种新发现的化合物座化学信号活跃在大脑的反应有效应力站饮酒过量，并防止复吸，酗酒。

The new, synthetic compound, known as MTIP, also muted the anxiety that typically develops in rats experiencing the equivalent of a hangover.新的合成化合物，称为mtip ，也平淡焦虑典型的发展经历大鼠相当于一个后遗症。 Such stress is linked with higher levels of a brain chemical called corticotropin-releasing factor (CRF), which is also thought to trigger relapse in rats that have developed a long-term dependency on alcohol.这种压力是与更高水平的脑部化学称为促肾上腺皮质激素释放因子（通用） ，这也被认为会引发复吸大鼠已经制定了一个长期依赖酒精。 The research, by Markus Heilig, MD, PhD, at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and his team, appears in the March 7, 2007 issue of The Journal of Neuroscience .研究中，马库斯heilig ，海事，博士学位，在国立酒精滥用和酒精中毒（本报讯） ，和他的团队，出现在2007年3月7日发行的杂志神经病 。

“This study shows the activity of a compound that potentially could be used in human subjects,” says George Koob, PhD, of the Scripps Research Institute. "这项研究显示活性化合物，有可能被用于人体， "乔治说，接到博士的斯克里普斯研究所。 “It moves the field over another translational barrier, closer to the day when the dark side of addiction is treated.” "这举动场平移另一个障碍，接近一天的阴暗面成瘾治疗" 。

The new findings build on previous work showing the effectiveness of blocking certain CRF receptors — proteins that bind CRF and make it active — in treating alcohol dependence in animals.新的研究结果，借鉴以往的工作，显示效果阻断某些通用受体-蛋白质结合通用使它活跃-在治疗酒精依赖于动物。 CRF levels in the brain rise in the short term after drinking; in subjects that are not dependent, this activation returns to normal within a day or so.通用水平在大脑崛起，在短期内喝完;科目是不依赖，这活化回到正常一天左右。 The new study shows that the CRF system becomes overactive in the long term in animals with a history of alcohol dependence, increasing the risk for relapse.新的研究表明，通用系统变得过于在长期动物史酒精依赖，增加风险为复发。

Heilig and his team showed that MTIP blocked the activity of CRF in stressful situations without affecting its activity under ordinary circumstances. heilig和他的团队显示mtip阻断活性通用压力的情况而不影响其活性正常情况下。 They studied rats that had been put through several cycles of heavy alcohol consumption and withdrawal to create dependency, as well as animals selectively bred to consume more alcohol.他们研究了老鼠已经通过几个周期重型酒精消费和撤出创造依赖，以及动物的选择性繁殖以消耗更多酒精。 Injections of MTIP prevented excessive drinking of alcohol in both cases and eliminated the rats’ susceptibility to relapse under stress.注射mtip阻止过量饮用酒精在这两种情况下，消灭老鼠的易感性复吸应激状态下。 Yet the compound did not affect their native curiosity or lower levels of drinking alcohol in rats that were not alcohol-dependent.然而复方并不影响他们母语的好奇心或下级饮酒大鼠不被酒精依赖性。

In addition to alcoholism, the compound may prove to be useful in the treatment of depression or anxiety disorders, in which CRF levels can be especially high.除了酒精中毒，复方可能被证明是有益的，在治疗抑郁症或焦虑症，其中通用水平，可特别高。

The compound or similar molecules can be given orally, reach the brain in sufficient amounts to block more than 90 percent of certain brain CRF receptors, and do not accumulate in other organs, most importantly the liver, in ways that would cause concerns about potential side effects, says Heilig.复方或类似分子，可以给予口头达成脑足额阻挡百分之九十以上的某些脑通用受体，不积累，在其他器官，最重要的肝脏，方式会令人担心潜在方效果说， heilig 。

Editorial note: Part of the struggle of an alcohol-dependent person in his or her recovery is learning to manage stress in different ways, to minimize or avoid harmful stress, to get support in stressful times, and to “de-stress” in whatever healthy ways possible (and yes, that sometimes includes the use of nonaddictive psychotropic medications under expert monitoring).编辑注：部分斗争酒精依赖的人在他或她的复苏是学习应付压力，在以不同的方式，以减少或避免有害应力，以得到支持，在紧张的时候， "德强调"无论健康可能的方式（是的，有时候，包括使用nonaddictive精神科药物专家根据监测） 。 Even if the above research does not lead to a compound useful in alcohol-dependent humans, it might help people to understand why all the different components of the recovery process are critical for the maintenance of sobriety.即使上述研究并不导致复合有用酒精依赖人类，它有可能帮助人们理解，为什么所有的不同组件复苏进程非常关键的维修和戒酒。 Even if such medications that help normalize the stress response are proven effective, it is likely that there will still be the residual problem of the euphoria-seeking “urge” of the alcoholic, independent of stress, that will need to be managed or blunted in some way - Dr. Z.即使这种药品，帮助恢复正常的应激反应是行之有效的，它很可能仍然会有残余的问题，兴奋寻求"促请"酒精，独立的压力，这将需要加以管理或在钝化以某种方式-博士z .