Shorter wear time provides shorter duration of effect 穿较短的时间规定期限较短的影响

October 2006 — Shire announced that its Attention Deficit Hyperactivity Disorder (ADHD) patch, DAYTRANA tm (methylphenidate transdermal system), has significant efficacy in reducing the symptoms of ADHD in children aged 6 to 12 years, even when the ADHD patch is taken off earlier than the recommended nine hours. 2006年10月-郡宣布，其多动症（多动症）修补，胃肠™ （甲酯透皮系统） ，有显着疗效，在减少症状多动症的儿童在6岁至1 2岁，即使多动症补丁起飞较早比推荐九个小时。 The ability to remove the patch earlier than the recommended nine-hour wear time allows physicians the opportunity to manage the potential for late-day side effects, such as lack of appetite or difficulty sleeping.有能力清除修补提前推荐九个小时佩戴时间允许医师机会管理潜力晚一天的副作用，如食欲不振或难以入睡。 These phase IIIb clinical trial results were reported today at a major scientific and educational meeting of child and adolescent psychiatrists in San Diego, Calif.这些iiib期临床试验结果报告今天正处于一个重大的科学和教育次儿童及青少年精神科位于美国加州圣地牙哥市

“The patch’s delivery system offers physicians individualized control of their patients’ ADHD symptoms, adding an important dimension to the treatment of ADHD, since a child’s schedule often varies between school day and weekend,” explained Timothy E. Wilens, M.D., Clinical and Research Program in Pediatric Psychopharmacology at Massachusetts General Hospital and Associate Professor of Psychiatry at Harvard Medical School. "补丁的配送系统提供个性医师控制病人的症状，过动，加入的一个重要方面，在治疗多动症的，因为孩子的时间表往往介于上课和周末， "解释提摩太e. wilens ，米。 d. ，临床及研究计画在小儿热病在马萨诸塞州总医院和精神病学副教授哈佛大学医学院。 “Because it is a patch, if a child sleeps late on the weekend and the patch is applied later than on a school day, it can still be removed at the usual time. " ，因为它是一个补丁，如果一个孩子睡迟于本周末和修补应用迟于一所学校一天，它仍然可以去除通常时间。 That way, the child receives the benefit of their long-acting ADHD medication for a shorter duration of effect, as well as managing the potential for late-day side effects.这样，孩子得到的好处，他们长效多动症用药期限较短的影响，以及管理的潜力晚一天的副作用。 The physician, in consultation with the parent, can determine the appropriate patch wear time, up to the recommended nine hours.”医师，在与父母，可确定适当修补磨损的时候，最多推荐九个小时。 "

Shire’s DAYTRANA is the first and only patch medication approved by the U.S. Food and Drug Administration (FDA) to treat the symptoms of pediatric ADHD. shire的胃肠是首只修补药物通过美国食品和药物管理局（ fda ）治标小儿多动症。 DAYTRANA is available in four dosage strengths – 10 mg, 15 mg, 20 mg and 30 mg – all designed for once-daily use.胃肠可在四个剂量的强项-1 0毫克， 1 5毫克， 2 0毫克和3 0毫克-所有旨在为每日一次使用。 When worn for the recommended nine hours, efficacy has been demonstrated from the first time point measured (two hours) through the 12-hour time point.时所穿为推荐九个小时，功效已证明，从第一次测点（两小时） ，通过12小时的时间点。

Noven Pharmaceuticals, Inc. developed DAYTRANA, which combines the active ingredient, methylphenidate, with Noven’s patented DOT Matrixä transdermal technology.业余时间制药公司开发的器质性疾病，结合活性成分，甲酯，刺鼻的专利dot matrixä透皮吸收技术。 This transdermal delivery system was designed to provide continuous medication release throughout the day.这种透皮给药系统的设计是为了提供连续服药释放整个一天。 The patch is designed to stay on during the normal daily activities of a child such as swimming, exercising or bathing.补丁是为了留在正常的日常活动，孩子如游泳，运动或洗澡。

Significant Symptom Control With DAYTRANA When Worn for Four or Six Hours 显症状控制与胃肠时所穿的四或六小时

In this study, investigators researched the duration of symptom control of DAYTRANA when the patch was worn for four and six hours compared to a placebo patch.在这项研究，调查研究的时间控制症状的器质性疾病时，修补被磨损为4到6个小时相比，安慰剂贴片。 Improvement in the scores for both the four- and six-hour wear time groups was seen at the first time point measured (2 hours), compared to placebo.改善得分均四和六小时的时间磨损组看到，在第一时间点测（ 2小时） ，比安慰剂。 When DAYTRANA was removed after four and six hours of wear time, mean scores began to return toward baseline within two hours of patch removal.当胃肠被拆除后， 4个和6个小时的时间磨损，平均得分开始返回基线对前两小时内清除修补。

Study Safety Information 研究信息安全

DAYTRANA was generally well-tolerated during this study.胃肠普遍具有良好的耐受性，在这项研究。 Adverse events typically were mild to moderate and were consistent with known effects of methylphenidate.不良反应事件通常是轻度至中度，并符合已知的影响甲酯。 The most common adverse events seen in the trial included: decreased appetite, headache, insomnia and upper abdominal pain.最常见的不良反应事件主要表现在审判包括：食欲下降，头痛，失眠及上腹部疼痛。

Important Safety Information 重要的安全信息

Tell your doctor about any heart conditions, including structural abnormalities, your child or a family member may have.告诉你的医生询问心脏任何条件，包括结构异常，你的孩子或家人可能有。 Inform your doctor immediately if the child develops symptoms that suggest heart problems, such as chest pain or fainting.告知你的医生立即如果孩子症状的发展表明心脏问题，如胸痛或晕厥。

Daytrana should not be used if the child has: allergies to methylphenidate or other ingredients of Daytrana; glaucoma; discontinued in the last 14 days or is taking a monoamine oxidase inhibitor (MAOI); tics, or family history or diagnosis of Tourette’s syndrome.胃肠不应该用，如果孩子有：过敏甲酯或其他成分胃肠;青光眼;在中断近14天或正在采取一种单胺氧化酶抑制剂（胺） ;月tics ，或家族病史或诊断抽动症。

Tell your doctor before using Daytrana if the child: is being treated for or has symptoms of depression (e.g. sadness, worthlessness, or hopelessness) or bipolar disorder; has family history of tics; has abnormal thoughts or visions, hears abnormal sounds, or has been diagnosed with psychosis; has had seizures or abnormal EEGs; has or has had high blood pressure; exhibits aggressive behavior or hostility.告诉你的医生，然后用胃肠如果孩子：正在接受治疗，或有抑郁症状（如悲伤，无能，或绝望）或躁郁症;有家族遗传史的tics ;有异常的想法或看法，听到异常声音或已被诊断患有精神病;已经发作或脑电图异常;已经或有血压高;展品攻击行为或敌意。 Tell your doctor immediately if the child develops any of these conditions/symptoms while using Daytrana.告诉你的医生立即如果孩子的发展有这些条件/症状，而用胃肠。

Daytrana was generally well tolerated in clinical studies.胃肠一般耐受性良好，在临床研究。 The most common side effects reported with Daytrana were decreased appetite, sleeplessness, sadness/crying, twitching, weight loss, nausea, vomiting, tics, and lability of affect (mood swings).最常见的副作用报道与胃肠降低食欲，失眠，哀伤/哭泣，抽搐，体重减轻，恶心，呕吐的tics ，不稳的影响（情绪波动） 。 Aggression, new abnormal thoughts/behaviors, mania, and growth suppression have been associated with use of drugs of this type.侵略，新的异常想法/行为，躁狂症，并生长抑制已与使用毒品这一类。 Tell your doctor if the child has blurred vision while using Daytrana.告诉你的医生，如果孩子有视力模糊，而用胃肠。

Abuse of Daytrana can lead to dependence.侵犯胃肠可引起依赖性。

Patients converting from another formulation of methylphenidate should start on the 10-mg DAYTRANA patch.病人转换，从另一个制订甲酯应该开始对10毫克胃肠修补程序。 Daytrana should be applied daily to clean, dry skin, which is free of any cuts or irritation.胃肠应适用于日常清洁，皮肤干燥，即无任何裁员或刺激性。 Skin irritation or allergic skin rash may occur.皮肤红肿或过敏性皮疹可能发生。

The study was supported by funding from Shire . 研究支持经费从郡 。

For Full Prescribing Information on Daytrana, please visit为充分处方信息对胃肠，请访问 www.Daytrana.com www.daytrana.com or call Shire Medical Affairs at 1-800-828-2088, option 1.或致电shire的医疗事务1-800-828-2088 ，选择1 。

About ADHD 约多动症

ADHD is one of the most common psychiatric disorders in children and adolescents.多动症是一种最常见的精神疾病，在儿童和青少年。 ADHD is a neurobiological psychiatric disorder that manifests as a persistent pattern of inattention and/or hyperactivity-impulsivity that is more frequent and severe than is typically observed in individuals at a comparable level of development.多动症是一种神经精神障碍，表现为一种持续的模式不注意和/或动-冲动是更加频繁和严重的是比一般观察个人在一个可比的发展水平。 Although there is no “cure” for ADHD, there are accepted treatments that specifically target its symptoms.虽然没有"治愈"多动症，有接受治疗的具体目标，其症状。 The most common standard treatments include educational approaches, psychological or behavioral modification, and medication.  (Courtesy of EurekAlert!, a service of AAAS)最常见的标准治疗方法包括教育方法，心理或行为修正，并服药。 （礼貌风行！ ，服务促）