Ohio State University – A new study suggests that people whose diets contain dramatically more omega-6 polyunsaturated fatty acids than omega-3 fatty acids may be at greater risk for both clinical depression and certain inflammatory diseases. While both omega-6 and omega-3 are polyunsaturated, their effects on the body are very different.

The report, published online this week in the journal Psychosomatic Medicine, suggests that we need to balance out our intake of omega-6 and omega-3 fatty acids. The current typical American diet contains 20 times more omega-6 than omega-3, a ratio that researchers say should be lowered to 4-to-1, or even 2-to-1.

This is the most recent in a long series of experiments Ohio State University researchers have conducted on the links between psychological stress and immunity. The addition of dietary questions to studies that have previously focused solely on emotional and biochemical markers may yield important new clues about the immune system. This research was supported in part by the NIH.

“In this study, we’re looking at the intersection of behavior, immune function and diet. In past experiments, we concentrated only on the first two,” explained Jan Kiecolt-Glaser, professor of psychiatry and psychology at Ohio State and lead author on the paper.

“It now appears that diet is a very important variable in the equation as to how people respond to depression and stress.”

The study, conducted in OSU’s Institute for Behavioral Medicine Research, focused on a group of 43 middle-aged to elderly men and women, nearly half of which were the caregiver spouses of people with Alzheimer’s or other dementias. By including caregivers who typically report greater stress and more depression than similar adults who are not stressed caregivers, the researchers could look at how depression and diet might interact to affect inflammation.

Blood samples were drawn from each person in the study and tested for interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha ) and the receptor molecule for IL-6. Participants also completed a survey questionnaire that gauged their level of depression.

The analysis showed that participants who had much more omega-6 than omega-3 fatty acids, and who also were reporting more symptoms of depression, had much higher levels of IL-6 and TNF-alpha, two cytokines which enhance inflammation.

“The data suggest that higher depression and a poorer diet in terms of omega-3 can work together to promote inflammation. Other researchers have shown that clinically depressed people — those with more severe depression — often have lower omega-3 levels in their blood, and several studies have shown that supplementing diets with omega-3 improves depression,” Kiecolt-Glaser said, although the reason isn’t clear.

“People who are depressed don’t eat well, or it might be that there is something about depression that affects how well people process such foods.”

In recent years, research has shown that an increase in omega-3 fatty acids in the diet has specific health benefits, especially in patients with depression, cardiovascular disease and inflammatory and autoimmune diseases.

Martha Belury, an associate professor of human nutrition, endocrinology, diabetes & metabolism at Ohio State and co-author of the omega-3 study, said the design of the study was important.

“We looked at people who were experiencing real depression, not those whose depression arose as a part of some experiment, and we could clearly see a relationship between lower omega-3 fatty acids and certain markers of depression and inflammation.”

Belury said that current recommendations allow up to two servings each week of cold-water fish – the best source of omega-3 – such as salmon or trout. This would not apply to pregnant women, she said, where concerns are greater about the heavy metal contamination such fish might contain (specifically mercury). Omega-3 fatty acids are also available as nutritional supplements; the most clinically tested omega-3 supplements are fish oil capsules or soft-gels, a few of which are enteric-coated for those with gastroesophageal reflux.

“This study has shown that even in people who did not take supplements, maybe just a little bit more omega-3 could help reduce their markers for both stress and depression,” Belury said.

“The important message for consumers is that they don’t have to take mega-doses of omega-3 fatty acids to have some impact. It might not take a whole lot to have a significant clinical impact,” Belury said.

Even the American Heart Association has recognized the importance of omega-3 oils from fish for heart health. If you are concerned about your cardiovascular health, preventing depression, reducing harmful inflammation, and obtaining the other benefits of omega-3 consumption, consider a high quality fish oil supplement, and read other omega-3 news articles at the iHealthBulletin News weblog for more information.


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